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Other Uses of the Ketogenic Diet

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 We know that the ketogenic diet can reduce and in some cases even completely stop seizures, there are many factors that may be involved in this process, ketones, glucose reduction, calorie restriction, and goodness knows what else within the complexities of the brain. Some aspects may be necessary for some, but perhaps not for all?
There has been a lot of speculation on whether the Ketogenic diet may be effective in other neurological disorders; a small amount of research is starting to appear. We have a Mum on site trying Keto for her child with a brain tumor, already seeing improvement!
 Who knows what the future may be, perhaps Alzheimer’s patients being treated with Atkins or MCT, or Motor neuron disease patients treated with Ketocal! 
 

Why Keto?

Rho J (2004) devoted a whole chapter to neuroprotection and the epileptogenic effect of the Ketogenic diet; he concluded that many different mechanisms are at work and that of course further research is needed!

Baranano K & Hartman A (2008)
http://www.springerlink.com/content/a623043470841350/fulltext.pdf?page=1

Dingledine R. (2005) Found that the Ketogenic diet improves neuronal stability and enhances ability to withstand metabolic changes.
http://www.sciencedaily.com/releases/2005/11/051114220938.htm

Gasior et al (2006) Neuroprotective, antioxidant, anti inflammatory? May be effective following traumatic brain injury and stroke!
Behavioral Pharmacology 17 431-439

Zhao. Z et al (2006) Found that ketones protect against neuronal death.
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1488864

 

References and further reading may be available for this article. To view references and further reading you must purchase this article.


Reger M et al (2004) Found that ketones improved cognition in memory impaired adults.
http://www.ncbi.nlm.nih.gov/pubmed/15123336

Veech et al are convinced that ketones can be used to treat other disorders and are set on developing an inexpensive form of oral ketone medication!

http://www.niaaa.nih.gov/ResearchInformation/IntramuralResearch/AboutDICBR/LMC/

USE OF KETOGENIC DIET TO TREAT CANCER

Although little research is as yet available, this is an area that looks very promising. The theory is that cancerous tumors need glucose for energy to grow. The link below looks at this hypothesis.
http://www.newtreatments.org/Cancer%20Treatment/ga/366

Effects of a Ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports.

Nebeling L et al (1995)
Tisdale MJ et al (1987)
http://charm.cs.uiuc.edu/users/jyelon/lowcarb.med/topic8.html


Thomas N. Seyfried, 2006, Metabolic Targeting of Brain Cancer

References and further reading may be available for this article. To view references and further reading you must purchase this article.

Alzheimer’s disease

Signs of Alzheimer’s in its early stages – Is it a type of diabetes?
http://www.eurekalert.org/pub_releases/2005-03/l-rdl030205.php

Auwera I et al (2005) Found that a Ketogenic diet reduced Beta Amyloid, a protein which becomes raised in Alzheimer’s patients.
http://www.nutritionandmetabolism.com/content/2/1/28/abstract

Alzheimer’s linked to diabetes;
Arvanitakis Z (2004) Found an increased risk of developing Alzheimer’s disease in those with Diabetes.
http://archneur.ama-assn.org/cgi/content/abstract/61/5/661?etoc

Diabetes

There is a doctor in USA with Type 1 Diabetes, a Dr Bernstein,  he swears by the ketogenic diet to control his diabetes, runs his own clinic, and advises the diet should be very closely supervised!
http://www.diabeteswellbeing.com/diabetes-diet.html

Willi S et al (2004) Found that an Atkins type diet had a stabilizing effect  on blood glucose, also reduced medication required in a small trial on adolescents with diabetes.
http://www.medicalnewstoday.com/articles/6145.php

Yancy Jr et al (2005) Showed similar results in a trial of patients with type 2 Diabetes
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1325029&rendertype=abstract

Yamada et al (2005) The Ketogenic diet reduces neuronal death, caused by hypoglycaemia.
Dashti et al (2007) Beneficial effects of KD in obese diabetic subjects.

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1464156
http://www.ncbi.nlm.nih.gov/pubmed/17447017?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=2&log$=relatedarticles&logdbfrom=pubmed

 Nielsen J and Joensson E (2008) Low cho diet for Diabetes Follow up.

http://www.nutritionandmetabolism.com/content/5/1/14

Bipolar

Some AED’s are used for Bipolar, so it’s possible that The diet may also help?!
Maloney C (2006)
 http://www.maloneymedical.com/id25.html
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=11918434&ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum

Study at Stanford University was discontinued due to lack of interested participants! ( Maybe Atkins or Low GI would be more appealing!)


Amyotrophic Lateral Sclerosis

Zhao et al (2006) Found that the ketogenic diet altered progression of the disease, by protecting against neuronal death and increasing the electrical potential between the mitochondria and cytoplasm.
http://www.biomedcentral.com/1471-2202/7/29/abstract

 
Autism

Evangeliou et al (2003) 60% of the children showed some improvement on a ketogenic diet.
http://jcn.sagepub.com/cgi/content/abstract/18/2/113 

ADHD

Canadian animal study found the Ketogenic diet may be effective in reducing hyperactivity.
http://www.ncbi.nlm.nih.gov/pubmed/16750194


Migraine


Menninger, W. (1932) Looked at using ketogenic diets for migraine, more recently Strahlan (2006) has seen positive results in a case study sited in Freeman J et al (2007) Ketogenic diet a decade on.

http://journals.lww.com/jonmd/Citation/1932/01000/Migraine_and_Its_Treatment_With_Ketogenic_Diet.25.aspx
http://pediatrics.aappublications.org/cgi/content/full/119/3/535

Narcolepsy

Husain A et al (2003) Found modest improvements after 8 weeks in a small study, using a ketogenic diet to treat narcolepsy.
http://www.neurology.org/cgi/content/abstract/62/12/2300


Parkinson’s Disease

Przedborski S (2003) Found in an animal study that an infusion of ketones reduced symptoms of Parkinson’s. 
http://hum-molgen.org/NewsGen/09-2003/000026.html

Vanltallie B (2005)A small study with Parkinson’s patients looks promising, though not conclusive.
http://www.neurology.org/cgi/content/abstract/64/4/728

Science Direct look at Vanltallie’s study.
 http://findarticles.com/p/articles/mi_m1200/is_9_167/ai_n13595718

http://www.direct-ms.org/pdf/NutritionNonAuto/Parkinson's%20and%20ketagenic%20diet.pdf

Jabre M et al (2006)
http://www.neurology.org/cgi/content/full/66/4/617

Tourettes pilot study

http://clinicaltrials.gov/ct2/show/NCT00952601

Thyroid Health

http://www.coconutdiet.com/thyroid_health.htm

Hyperinsulinemia Diseases of Civilization

Interesting, Perhaps we should all be looking at our carbohydrate consumption?!
Syndrome X
http://www.lowcarb.ca/articlesb/article344.html

Fishel et al (2005)
http://archneur.ama-assn.org/cgi/content/abstract/62/10/1539


Volek J & Feinman R (2005) Hypothesize that a low carbohydrate diet may control Insulin levels and so improve the features of Metabolic Syndrome.
http://www.nutritionandmetabolism.com/content/2/1/31


Medical News Today (2007) Linking Polycystic Ovary Syndrome to Hyperinsulinemia.
http://www.medicalnewstoday.com/medicalnews.php?newsid=65154 

Mavropoulos et al (2005) A small study, Ketogenic diet for Polycystic ovary Syndrome.
http://www.ncbi.nlm.nih.gov/sites/entrez?Db=Pubmed&Cmd=ShowDetailView&TermToSearch=16359551&ordinalpos=4&itool=Entre

Heart Disease

Initially Keto looks like a bad choice where heart disease is concerned!
http://www.escholarship.org/uc/item/6ns1g93v

 
Groesbeck et al (2006) Looking better!
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=548112 

Johns Hopkins (2008) High cholesterol drops naturally in children on high-fat anti-seizure diet.

http://www.vidyya.com/vo110/v10i227_1.htm

Stafstrom C & Rho J (2004) Found by altering fat content in the diet, IE ‘good’ fat for ‘bad’ fat improved Cholesterol/HDL levels.????

Best T et al (2000) Notes some children on the Ketogenic diet show a prolonged QT interval on ECG investigation.
http://www.cincinnatichildrens.org/about/news/release/2000/7-diet.htm

Bergqvist A et al (2003) Noted a risk of selenium deficiency leading to cardiomyopathy in one child. http://www.ingentaconnect.com/content/bsc/epi/2003/00000044/00000004/art00018


Carrie Loughran MF USA link dietician has found that adding Carnitine supplement decreases lipid levels (MF conference 2006). As carnitine deficiency can lead to Cardiomyopathy, it should be considered, AED’s may have already depleted carnitine levels.

Interestingly there is a Dr Clark at oxford University conducting animal research and found an alternative energy source (ketones) improve energy uptake in heart failure! She also stated that the diet is ‘hideous’ and would be ‘disastrous’ for a coronary patient. ( must remember to send her one of our recipe books!

Even so

Halton T (2002) In a health study of 82,802 women, found that following a ketogenic type diet did not increase the risk of heart disease, infact, if vegetable fats and proteins are used, there could well be a reduction in risk of heart disease!

http://content.nejm.org/cgi/content/abstract/355/19/1991

Shai I et al (2008)
http://content.nejm.org/cgi/content/full/359/3/229


Westman E et al (2005) Compare Keto to Low fat diet
Low carb diet for heart disease?

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T16-4HK5SGV-4&_user=10&_origUdi=B6VJW-4KDCHD8-4&_fmt=high&_coverDate=06%2F16%2F2006&_rdoc=1&_orig=article&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=1da16784e1926f625f68c7b17ef2f179

Low-fat and low-carbohydrate diets can be equally effective at helping obese adults shed weight over the longer term, but cutting carbs may have an advantage when it comes to some heart risk factors, a study published Monday suggests.

http://www.reuters.com/article/idUSTRE6720AV20100803

So conflicting evidence there! But I have to say I am no longer a low fat, high carb fan!

Traumatic brain injury

http://www.ingentaconnect.com/content/apl/tbin/2009/00000023/00000005/art00010

http://www.biomedsearch.com/nih/effects-ketogenic-diet-behavioral-outcome/19231995.html


There are  I am sure other articles and there will be more to come, please add to this section if you find further studies! I will be updating as new research comes in!

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